Allopurinol

The label describes allopurinol for primary or secondary gout, for raised uric acid in patients receiving cancer therapy, and for recurrent calcium oxalate stones with high uric acid excretion.

The label says it is not recommended for asymptomatic hyperuricaemia.

• Gout
• Raised uric acid during cancer therapy
• Recurrent calcium oxalate stones

The label says allopurinol inhibits xanthine oxidase, the enzyme that makes uric acid from hypoxanthine and xanthine.

Its active form, oxypurinol, also inhibits this enzyme. It does not disrupt the building of purines.

This page covers the US label for allopurinol tablets taken by mouth, with the dosing the label gives for adults.

This is label-level information, not personal advice. Indian pack labels may differ, and your prescriber's instruction always comes first.

For adults, the label describes starting at a low dose of 100 mg daily and increasing by 100 mg at weekly intervals until uric acid is 6 mg/dL or less, without going above 800 mg daily.

The label gives an average of 200 to 300 mg daily for mild gout and 400 to 600 mg daily for moderately severe tophaceous gout. Doses above 300 mg are divided.

The low start helps reduce the risk of gout flare-ups. Colchicine or anti-inflammatory drugs are usually continued while adjusting the dose.

• Start at 100 mg daily
• Increase weekly by 100 mg
• Doses above 300 mg are divided
• Maximum 800 mg daily

The label says it must not be restarted in a patient who developed a severe reaction to allopurinol. It should be stopped at the first appearance of rash or allergic signs.

Liver function tests are advised in those with liver disease. Allergic reactions may be more frequent with reduced kidney function and thiazides together.

The label advises caution when alertness is needed, because drowsiness can occur.

• Previous severe reaction to allopurinol
• Rash or allergic signs
• Liver disease
• Reduced kidney function
• Drowsiness

• Mercaptopurine and azathioprine
• Dicumarol
• Uricosuric agents
• Thiazide diuretics
• The label says that with mercaptopurine or azathioprine, the dose of those drugs must be cut to about one-third to one-quarter.
• It may prolong the effect of dicumarol.
• Uricosuric agents and thiazide diuretics also interact.

No match in this label text. Ask your pharmacist about any medicine you take.

The label gives a storage range of 20 to 25 degrees C.

The label also says to keep the container tightly closed.

Follow the storage line on your own pack, and keep medicines out of the reach of children.

We did not find allopurinol in the Drugs Rules 1945 Schedule H, H1, X or G rows we checked, so we cannot state its Indian prescription status from our lists. Ask your pharmacist or doctor.

Allopurinol is on the National List of Essential Medicines 2022. Listed forms include: Tablet 100 mg (page 62); Tablet 300 mg (page 62); Tablet 100 mg (page 84).

NPPA lists ceiling prices for scheduled allopurinol formulations. The table shows the rows we found. Check NPPA directly for the current list.

The Jan Aushadhi (PMBJP) list we checked has 2 product rows that mention allopurinol. We did not capture prices for them.

NPPA ceiling prices set the most a seller can charge per unit for the listed formulations, before local taxes. They are ceilings, not the price you will always pay.

Jan Aushadhi lists allopurinol products including Allopurinol Tablets IP 100 mg 100 mg; Allopurinol Tablets IP 300 mg 300 mg. We have not shown a price for them. Check the pack and the seller for the actual price.