How should I take Celecoxib?

2. DOSAGE AND ADMINISTRATION Use the lowest effective dosage for shortest duration consistent with individual patient treatment goals. ( 2.1 ) OA: 200 mg once daily or 100 mg twice daily. ( 2.2 , 14.1 ) RA: 100 mg to 200 mg twice daily. ( 2.3 , 14.2 ) JRA: 50 mg twice daily in patients 10 kg to 25 kg. 100 mg twice daily in patients more than 25 kg. ( 2.4 , 14.3 ) AS: 200 mg once daily single dose or 100 mg twice daily. If no effect is observed after 6 weeks, a trial of 400 mg (single or divided doses) may be of benefit. ( 2.5 , 14.4 ) AP and PD: 400 mg initially, followed by 200 mg dose if needed on first day. On subsequent days, 200 mg twice daily as needed. ( 2.6 , 14.5 ) Hepatic Impairment: Reduce daily dose by 50% in patients with moderate hepatic impairment (Child-Pugh Class B). ( 2.7 , 8.6 , 12.3 ) Poor Metabolizers of CYP2C9 Substrates: Consider a dose reduction by 50% (or alternative management for JRA) in patients who are known or suspected to be CYP2C9 poor metabolizers. ( 2.7 , 8.8 , 12.3 ). 2.1 General Dosing Instructions Carefully consider the potential benefits and risks of celecoxib and other treatment options before deciding to use celecoxib. Use the lowest effectiv

What are the common side effects?

6., ADVERSE REACTIONS The following adverse reactions are discussed in greater detail in other sections of the labeling: Cardiovascular Thrombotic Events [ see Warnings and Precautions ( 5.1 ) ] GI Bleeding, Ulceration and Perforation [ see Warnings and Precautions ( 5.2 ) ] Hepatotoxicity [ see Warnings and Precautions ( 5.3 ) ] Hypertension [ see Warnings and Precautions ( 5.4 ) ] Heart Failure and Edema [ see Warnings and Precautions ( 5.5 ) ] Renal Toxicity and Hyperkalemia [ see Warnings and Precautions ( 5.6 ) ] Anaphylactic Reactions [ see Warnings and Precautions ( 5.7 ) ] Serious Skin Reactions [ see Warnings and Precautions ( 5.9 ) ] Hematologic Toxicity [ see Warnings and Precautions ( 5.12 ) ] Most common adverse reactions in arthritis trials (>2% and > placebo) are: abdominal pain, diarrhea, dyspepsia, flatulence, peripheral edema, accidental injury, dizziness, pharyngitis, rhinitis, sinusitis, upper respiratory tract infection, rash., ( 6.1 ) To report SUSPECTED ADVERSE REACTIONS, contact Micro Labs USA, Inc., at 1-855-839-8195 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch 6.1 Clinical Trials Experience Because clinical trials are conducted under widely varying condit.

Who should not take Celecoxib?

4.; CONTRAINDICATIONS Celecoxib is contraindicated in the following patients: Known hypersensitivity (e.g., anaphylactic reactions and serious skin reactions) to celecoxib, any components of the drug product [see Warnings and Precautions (5.7, 5.9) ].; History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs.; Severe, sometimes fatal, anaphylactic reactions to NSAIDs, have been reported in such patients [see Warnings and Precautions (5.7 , 5.8) ].; In the setting of CABG surgery [see Warnings and Precautions (5.1) ].; In patients who have demonstrated allergic-type reactions to sulfonamides [see Warnings and Precautions (5.7) ]..

Can I take Celecoxib during pregnancy?

8.1 Pregnancy Risk Summary Use of NSAIDs, including celecoxib, can cause premature closure of the fetal ductus arteriosus and fetal renal dysfunction leading to oligohydramnios and, in some cases, neonatal renal impairment. Because of these risks, limit dose and duration of celecoxib use between about 20 and 30 weeks of gestation and avoid celecoxib use at about 30 weeks of gestation and later in pregnancy ( see Clinical Considerations, Data ). Premature Closure of Fetal Ductus Arteriosus Use of NSAIDs, including celecoxib, at about 30 weeks gestation or later in pregnancy increases the risk of premature closure of the fetal ductus arteriosus. Oligohydramnios/Neonatal Renal Impairment Use of NSAIDs at about 20 weeks gestation or later in pregnancy has been associated with cases of fetal renal dysfunction leading to oligohydramnios, and in some cases, neonatal renal impairment. Data from observational studies regarding other potential embryofetal risks of NSAID use in women in the first or second trimesters of pregnancy are inconclusive. In animal reproduction studies, embryo-fetal deaths and an increase in diaphragmatic hernias were observed in rats administered celecoxib daily dur

Can I take Celecoxib while breastfeeding?

8.3 Females and Males of Reproductive Potential Infertility Females Based on the mechanism of action, the use of prostaglandin-mediated NSAIDs, including celecoxib, may delay or prevent rupture of ovarian follicles, which has been associated with reversible infertility in some women. Published animal studies have shown that administration of prostaglandin synthesis inhibitors has the potential to disrupt prostaglandin mediated follicular rupture required for ovulation. Small studies in women treated with NSAIDs have also shown a reversible delay in ovulation. Consider withdrawal of NSAIDs, including celecoxib, in women who have difficulties conceiving or who are undergoing investigation of infertility.

Can children take Celecoxib?

8.4 Pediatric Use Celecoxib is approved for relief of the signs and symptoms of Juvenile Rheumatoid Arthritis in patients 2 years and older. Safety and efficacy have not been studied beyond six months in children. The long-term cardiovascular toxicity in children exposed to celecoxib has not been evaluated and it is unknown if long-term risks may be similar to that seen in adults exposed to celecoxib or other COX-2 selective and non- selective NSAIDs [see Boxed Warning, Warnings and Precautions (5.5) , and Clinical Studies (14.3) ]. The use of celecoxib in patients 2 years to 17 years of age with pauciarticular, polyarticular course JRA or in patients with systemic onset JRA was studied in a 12-week, double-blind, active controlled, pharmacokinetic, safety and efficacy study, with a 12-week open-label extension. Celecoxib has not been studied in patients under the age of 2 years, in patients with body weight less than 10 kg (22 lbs), and in patients with active systemic features. Patients with systemic onset JRA (without active systemic features) appear to be at risk for the development of abnormal coagulation laboratory tests. In some patients with systemic onset JRA, both celecox

Does Celecoxib interact with other medicines?

7.; DRUG INTERACTIONS See Table 3 for clinically significant drug interactions with celecoxib.; Table 3: Clinically Significant Drug Interactions with Celecoxib Drugs That Interfere with Hemostasis Clinical Impact: Celecoxib and anticoagulants such as warfarin have a synergistic effect on bleeding.; The concomitant use of celecoxib and anticoagulants have an increased risk of serious bleeding compared to the use of either drug alone.; Serotonin release by platelets plays an important role in hemostasis.; Case-control and cohort epidemiological studies showed that concomitant use of drugs that interfere with serotonin reuptake and an NSAID may potentiate the risk of bleeding more than an NSAID alone..

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Medicines
Celecoxib

Illustration of the usual dosage form, not a product photo.

Chemical structure · PubChem CID 2662

NSAID (COX-2 inhibitor)Boxed warning: Cardiovascular and gastrointestinal riskPrescription only (Schedule H)

Celecoxib

सेलेकोक्सिब

Celecoxib is an NSAID capsule for arthritis, acute pain and period pain. It carries a boxed warning for serious heart, stroke and stomach or gut bleeding risks. The label advises the lowest effective amount for the shortest time. Ask your doctor or pharmacist before use.

Generic name: Celecoxib
Used for: Arthritis, ankylosing spondylitis, acute pain and painful periods, in adults and some children.
Label used: Capsules label, oral, DailyMed set 3a1eadd5, effective 2026-09
Prescription status (India): Prescription only (Schedule H) in the lists we checked
On NLEM 2022: Not found in the list we checked
NPPA price ceiling: Not listed in the lists we checked

More facts

Jan Aushadhi: Not found in the list we checked
Banned combinations: None found in the list we checked

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Compiled from official drug labels and Indian government sources. Always follow your doctor's or pharmacist's advice.

Safety at a glance

AlcoholNot mentioned in label text
PregnancyAvoid, per label textSee wording
BreastfeedingCaution in label textSee wording
DrivingCaution in label textSee wording
KidneyCaution in label textSee wording
LiverCaution in label textSee wording

Taken only from the label text cited on this page. "Not mentioned" does not mean safe. Ask your doctor or pharmacist.

What is celecoxib used for?

The label describes celecoxib for osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis in patients 2 years and older, and ankylosing spondylitis.

It is also described for acute pain in adults and primary dysmenorrhoea (painful periods).

Osteoarthritis
Rheumatoid arthritis
Juvenile rheumatoid arthritis from age 2
Ankylosing spondylitis
Acute pain and period pain

Source1

How does celecoxib work?

The label says celecoxib is believed to work by blocking prostaglandin production, mainly through COX-2.

Prostaglandins sensitise nerves to pain and mediate inflammation.

Source1

How is celecoxib usually taken?

This page covers the US label for celecoxib capsules taken by mouth, with the dosing the label gives for adults and, where the label says so, children.

This is label-level information, not personal advice. Indian pack labels may differ, and your prescriber's instruction always comes first.

The label says to use the lowest effective amount for the shortest time. Doses can be taken without regard to meals.

For adults, it describes 200 mg once daily or 100 mg twice daily for osteoarthritis, and 100 to 200 mg twice daily for rheumatoid arthritis. For acute pain and period pain, it describes an initial 400 mg, then 200 mg if needed.

Children with juvenile arthritis are dosed by weight. The label advises a 50% reduction in moderate liver impairment and in known CYP2C9 poor metabolisers.

Lowest effective amount, shortest time
With or without food
Children dosed by weight
Reduced in moderate liver impairment

Source1

What are the side effects of celecoxib?

Common

Abdominal pain, indigestion
Diarrhoea, gas
Dizziness, rash
Bleeding, heart or stroke events

Serious: get help

Common effects in arthritis trials were abdominal pain, diarrhoea, indigestion, gas, swelling in the legs, dizziness, sore throat, runny nose, sinusitis, respiratory infection and rash.
Serious effects include heart attack, stroke, stomach or gut bleeding, ulcers and perforation, liver injury, high blood pressure, heart failure, kidney problems, allergic reactions and severe skin reactions.
Swelling in legs

Source1

Who should be careful with celecoxib?

Boxed warning: NSAIDs raise the risk of heart attack and stroke, which can be fatal, and of gut bleeding, ulcers and perforation, which can occur without warning. Elderly people and those with past ulcers are at higher risk.

It is contraindicated around coronary bypass surgery, with past asthma, hives or allergy after aspirin or NSAIDs, and with sulfonamide allergy.

The label advises avoiding it from about 30 weeks of pregnancy onward, and limiting use between about 20 and 30 weeks.

Boxed warning: heart and gut risk
Not around bypass surgery
Not with aspirin or NSAID allergy
Not with sulfonamide allergy
Avoid late in pregnancy

Source1

What medicines interact with celecoxib?

Search interactions

Warfarin and other anticoagulants
Aspirin and antiplatelets
SSRIs and SNRIs
The label names anticoagulants such as warfarin, antiplatelets such as aspirin, SSRIs and SNRIs, which raise bleeding risk.
It also lists aspirin, which adds no extra benefit with an NSAID, and other drugs affecting kidney function.
See the full label for further classes.

Source1

How should celecoxib be stored?

The label gives a storage range of 20 to 25 degrees C.

Follow the storage line on your own pack, and keep medicines out of the reach of children.

Source1

Is celecoxib a prescription medicine in India?

In the Drugs Rules schedules we checked, celecoxib is listed under Schedule H (serial and rule: Schedule H, serial 100 (rules 65 and 97)). Schedule H medicines are sold only on a registered doctor's prescription.

We did not find celecoxib on the National List of Essential Medicines 2022 in the list we checked.

Source2

Frequently asked questions

Can I drink alcohol while taking celecoxib?

The label we reviewed does not say. Ask your doctor or pharmacist.

Source1

Is celecoxib safe in pregnancy and breastfeeding?

The label advises limiting use between about 20 and 30 weeks and avoiding it from about 30 weeks, due to fetal heart and kidney risks. Breastfeeding is not covered here. Ask your doctor or pharmacist.

Source1

Should celecoxib be taken with food?

The label says doses can be taken without regard to the timing of meals.

Source1

Can celecoxib affect driving or alertness?

The label lists dizziness as a side effect. It gives no driving advice. Ask your doctor or pharmacist.

Source1

Can children or older adults take celecoxib?

The label describes use in juvenile arthritis from age 2, dosed by weight. Elderly people face higher gut bleeding risk. Ask your doctor or pharmacist.

Source1

Is celecoxib on the NLEM and Jan Aushadhi list?

We did not find it on NLEM 2022. We did not find celecoxib in the Jan Aushadhi list we checked.

Source2

Sources

1U.S. FDA-approved label (DailyMed) (3a1eadd5-c0a7-473e-bde0-6b9450d11c95) Open source · 2026-10-15
2Drugs Rules 1945, Schedules (2022 consolidation) (Schedule H, Schedule H, serial 100 (rules 65 and 97)) Open source · 2026-10-15

Compiled by software from the sources above and checked by automated rules. Last checked: 2026-10-15 · How we use sources · Report a correction

This information is educational and is not a substitute for advice from your doctor or pharmacist. It does not tell you what dose you personally should take. In an emergency call 112.

Safety at a glance

What is celecoxib used for?

How does celecoxib work?

How is celecoxib usually taken?

What are the side effects of celecoxib?

Common

Serious: get help

Who should be careful with celecoxib?

What medicines interact with celecoxib?

How should celecoxib be stored?

Is celecoxib a prescription medicine in India?

Frequently asked questions

Sources

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