Dapagliflozin

The label describes dapagliflozin for adults with type 2 diabetes who also have established cardiovascular disease or several risk factors, to reduce the risk of hospitalisation for heart failure.

It is also described as an add-on to diet and exercise to improve blood sugar control in adults with type 2 diabetes. It is not recommended for type 1 diabetes.

• Improve blood sugar control in type 2 diabetes
• Reduce heart failure hospitalisation risk in type 2 diabetes with heart disease or risk factors
• Not recommended for type 1 diabetes

Dapagliflozin blocks SGLT2, a protein in the kidneys that takes glucose back into the blood.

Blocking it makes the body pass more glucose in urine. The label also says it increases sodium loss, which may ease strain on the heart.

This page covers the US label for dapagliflozin tablets taken by mouth, with the dosing the label gives for adults.

This is label-level information, not personal advice. Indian pack labels may differ, and your prescriber's instruction always comes first.

For adults, the label describes a starting dose of 5 mg once daily for blood sugar control, which can be raised to 10 mg once daily. For heart failure risk reduction, it describes 10 mg once daily.

The label says kidney function and fluid status should be checked before starting. It is not recommended for blood sugar control when eGFR is below 45.

The label says to withhold it for at least 3 days, if possible, before surgery or procedures with prolonged fasting.

• 5 mg once daily to start, up to 10 mg
• 10 mg once daily for heart failure risk reduction
• Kidney function checked before and during use
• Withheld for at least 3 days before surgery with prolonged fasting

The label says not to use dapagliflozin if you have had a serious allergic reaction to it or its ingredients. It carries warnings for ketoacidosis, which can occur even with normal blood sugar.

Elderly people, those with kidney problems, low blood pressure or on diuretics need volume status checked. The label does not recommend use during the second and third trimesters of pregnancy.

• Do not use if seriously allergic to it
• Risk of ketoacidosis
• Risk of dehydration, especially in elderly or on diuretics
• Risk of serious genital and urinary infections
• Not recommended in the second and third trimesters of pregnancy
• Not for type 1 diabetes

• Insulin and sulfonylureas
• Lithium
• Urine glucose tests and 1,5-AG test results
• The label says the risk of low blood sugar rises with insulin or insulin secretagogues such as sulfonylureas, which may need lower doses.
• It may lower lithium levels.
• It also causes positive urine glucose tests and makes the 1,5-AG test unreliable.

No match in this label text. Ask your pharmacist about any medicine you take.

The label gives a storage range of 20 to 25 degrees C.

Follow the storage line on your own pack, and keep medicines out of the reach of children.

We did not find dapagliflozin in the Drugs Rules 1945 Schedule H, H1, X or G rows we checked, so we cannot state its Indian prescription status from our lists. Ask your pharmacist or doctor.

We did not find dapagliflozin on the National List of Essential Medicines 2022 in the list we checked.

The Jan Aushadhi (PMBJP) list we checked has 12 product rows that mention dapagliflozin. We did not capture prices for them.

Jan Aushadhi lists dapagliflozin products including Dapagliflozin Tablets 10 mg 10 mg; Dapagliflozin 10mg and Metformin Hydrochloride (Extended Release) 1000mg Tablets 10mg; Dapagliflozin 10mg and Metformin Hydrochloride (Extended Release) 500mg Tablets 10mg; Dapagliflozin Tablets 5mg 5mg. We have not shown a price for them. Check the pack and the seller for the actual price.