How should I take Glipizide?

DOSAGE AND ADMINISTRATION There is no fixed dosage regimen for the management of diabetes mellitus with glipizide or any other hypoglycemic agent. In addition to the usual monitoring of urinary glucose, the patient’s blood glucose must also be monitored periodically to determine the minimum effective dose for the patient; to detect primary failure, i.e., inadequate lowering of blood glucose at the maximum recommended dose of medication; and to detect secondary failure, i.e., loss of an adequate blood-glucose-lowering response after an initial period of effectiveness. Glycosylated hemoglobin levels may also be of value in monitoring the patient’s response to therapy. Short-term administration of glipizide may be sufficient during periods of transient loss of control in patients usually controlled well on diet. In general, glipizide should be given approximately 30 minutes before a meal to achieve the greatest reduction in postprandial hyperglycemia. Initial Dose The recommended starting dose is 5 mg, given before breakfast. Geriatric patients or those with liver disease may be started on 2.5 mg. Titration Dosage adjustments should ordinarily be in increments of 2.5 to 5 mg, as deter

What are the common side effects?

ADVERSE REACTIONS In U.S., and foreign controlled studies, the frequency of serious adverse reactions reported was very low., Of 702 patients, 11.8% reported adverse reactions and in only 1.5% was glipizide discontinued., Hypoglycemia See PRECAUTIONS and OVERDOSAGE sections., Gastrointestinal Gastrointestinal disturbances are the most common reactions., Gastrointestinal complaints were reported with the following approximate incidence: nausea and diarrhea, one in seventy;.

Who should not take Glipizide?

CONTRAINDICATIONS Glipizide is contraindicated in patients with: 1.; Known hypersensitivity to the drug.; 2.; Type 1 diabetes mellitus, diabetic ketoacidosis, with or without coma.; This condition should be treated with insulin..

Can I take Glipizide during pregnancy?

Pregnancy Glipizide was found to be mildly fetotoxic in rat reproductive studies at all dose levels (5 to 50 mg/kg). This fetotoxicity has been similarly noted with other sulfonylureas, such as tolbutamide and tolazamide. The effect is perinatal and believed to be directly related to the pharmacologic (hypoglycemic) action of glipizide. In studies in rats and rabbits, no teratogenic effects were found. There are no adequate and well controlled studies in pregnant women. Glipizide should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Because recent information suggests that abnormal blood glucose levels during pregnancy are associated with a higher incidence of congenital abnormalities, many experts recommend that insulin be used during pregnancy to maintain blood glucose levels as close to normal as possible. Nonteratogenic Effects Prolonged severe hypoglycemia (4 to 10 days) has been reported in neonates born to mothers who were receiving a sulfonylurea drug at the time of delivery. This has been reported more frequently with the use of agents with prolonged half-lives. If glipizide is used during pregnancy, it should be discontin

Can I take Glipizide while breastfeeding?

Nursing Mothers Although it is not known whether glipizide is excreted in human milk, some sulfonylurea drugs are known to be excreted in human milk. Because the potential for hypoglycemia in nursing infants may exist, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. If the drug is discontinued and if diet alone is inadequate for controlling blood glucose, insulin therapy should be considered.

Can children take Glipizide?

Pediatric Use Safety and effectiveness in children have not been established.

Does Glipizide interact with other medicines?

Drug Interactions The hypoglycemic action of sulfonylureas may be potentiated by certain drugs including non-steroidal anti-inflammatory agents, some azoles, and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, monoamine oxidase inhibitors, quinolones and beta-adrenergic blocking agents.; When such drugs are administered to a patient receiving glipizide, the patient should be observed closely for hypoglycemia.; When such drugs are withdrawn from a patient receiving glipizide, the patient should be observed closely for loss of control.; In vitro binding studies with human serum proteins indicate that glipizide binds differently than tolbutamide and does not interact with salicylate or dicumarol.; However, caution must be exercised in extrapolating these findings to the clinical situation and in the use of glipizide with these drugs.; Certain drugs tend to produce hyperglycemia and may lead to loss of control..

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Glipizide

Illustration of the usual dosage form, not a product photo.

Chemical structure · PubChem CID 3478

sulfonylureaIndian prescription status not found in lists checkedJan Aushadhi listedAppears in banned-combination list entries

Glipizide

ग्लिपिज़ाइड

Glipizide is a sulfonylurea tablet used with diet and exercise to improve blood sugar in adults with type 2 diabetes. It can cause low blood sugar. The label includes a special warning about higher cardiovascular death risk seen with this drug class, and it is not for type 1 diabetes.

Generic name: Glipizide
Used for: Improving blood sugar control in adults with type 2 diabetes, along with diet and exercise.
Label used: Tablets label, oral, DailyMed set 00729e82, effective 2026-08
Prescription status (India): Not found in the Schedule H/H1/X/G lists we checked
On NLEM 2022: Not found in the list we checked
NPPA price ceiling: Not listed in the lists we checked

More facts

Jan Aushadhi: Listed (2 product rows)
Banned combinations: 1 entries mention it; use the checker for your combination

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Compiled from official drug labels and Indian government sources. Always follow your doctor's or pharmacist's advice.

Safety at a glance

AlcoholCaution in label textSee wording
PregnancyCaution in label textSee wording
BreastfeedingCaution in label textSee wording
DrivingNot mentioned in label text
KidneyCaution in label textSee wording
LiverCaution in label textSee wording

Taken only from the label text cited on this page. "Not mentioned" does not mean safe. Ask your doctor or pharmacist.

What is glipizide used for?

The label describes glipizide as an add-on to diet and exercise to improve blood sugar control in adults with type 2 diabetes.

Type 2 diabetes in adults, with diet and exercise

Source1

How does glipizide work?

Glipizide appears to lower blood sugar by prompting the pancreas to release insulin, so it depends on working beta cells. How it works over long periods has not been clearly established.

Source1

How is glipizide usually taken?

This page covers the US label for glipizide tablets taken by mouth, with the dosing the label gives for adults.

This is label-level information, not personal advice. Indian pack labels may differ, and your prescriber's instruction always comes first.

The label says there is no fixed dose. Blood sugar is monitored regularly to find the lowest effective dose. It is generally given about 30 minutes before a meal.

The label describes a starting dose before breakfast, with a lower start for older people or those with liver disease. Adjustments are made in small steps several days apart.

Larger daily totals are usually divided and given before meals. The label states a maximum daily total.

About 30 minutes before a meal
Lower start for older or liver-impaired adults
Small adjustments several days apart
Larger totals divided across meals

Source1

What are the side effects of glipizide?

Common

Low blood sugar is the main concern. Stomach upset such as nausea, diarrhoea or constipation is most common and is often dose-related.
Skin reactions, rash and itching occur in some people. Rare effects include jaundice, low blood counts and light sensitivity.
Low blood sugar
Nausea, diarrhoea, constipation
Skin rash or itching
Rare jaundice or blood count changes

Serious: get help

Not listed separately in the label text we used.

Source1

Who should be careful with glipizide?

The label carries a special warning that oral glucose-lowering drugs have been associated with higher cardiovascular death than diet alone, based on a study of another sulfonylurea.

It must not be used in type 1 diabetes, diabetic ketoacidosis or after allergy to it. Older or debilitated people and those with kidney or liver problems are more prone to low blood sugar.

Cardiovascular mortality warning
Not for type 1 diabetes or ketoacidosis
Risk of low blood sugar
Care in older people and liver or kidney disease
Use in pregnancy only if benefit justifies risk
Regular blood sugar monitoring

Source1

What medicines interact with glipizide?

Search interactions

NSAIDs and salicylates
Sulfonamides, azoles, quinolones
Beta blockers and MAO inhibitors
Steroids, thiazide diuretics and thyroid products
The label says the blood sugar-lowering effect can be increased by NSAIDs, salicylates, sulfonamides, azoles, coumarins, MAO inhibitors, quinolones and beta blockers.
Thiazides and other diuretics, corticosteroids, thyroid products, estrogens, phenytoin and isoniazid may raise blood sugar and reduce control.

Source1

How should glipizide be stored?

The label gives a storage range of 20 to 25 degrees C.

The label also says to keep the container tightly closed.

Follow the storage line on your own pack, and keep medicines out of the reach of children.

Source1

Is glipizide a prescription medicine in India?

We did not find glipizide in the Drugs Rules 1945 Schedule H, H1, X or G rows we checked, so we cannot state its Indian prescription status from our lists. Ask your pharmacist or doctor.

We did not find glipizide on the National List of Essential Medicines 2022 in the list we checked.

The Jan Aushadhi (PMBJP) list we checked has 2 product rows that mention glipizide. We did not capture prices for them.

The banned fixed-dose combination list we checked has 1 entries that mention glipizide. This does not mean the single medicine is banned. Use our checker for a specific combination.

Source2

What is the price ceiling for glipizide?

Jan Aushadhi lists glipizide products including Glipizide Tablet IP 5 mg 5 mg; Glipizide 5mg and Metformin Hydrochloride 500mg Tablets 5mg. We have not shown a price for them. Check the pack and the seller for the actual price.

Source2

Frequently asked questions

Can I drink alcohol while taking glipizide?

The label we reviewed does not say clearly. Alcohol can affect blood sugar. Ask your doctor or pharmacist.

Source1

Is glipizide safe in pregnancy and breastfeeding?

The label says use in pregnancy only if the benefit justifies the risk, as it was fetotoxic in animals. Breastfeeding details were not in the text we reviewed. Ask your doctor or pharmacist.

Source1

Should glipizide be taken with food?

The label says it is generally given about 30 minutes before a meal. Ask your doctor or pharmacist.

Source1

Can glipizide affect driving or alertness?

The label we reviewed does not say, but low blood sugar can affect alertness. Ask your doctor or pharmacist.

Source1

Can children or older adults take glipizide?

The label covers adults with type 2 diabetes only. Older adults may start at a lower dose. Ask your doctor or pharmacist.

Source1

Is glipizide on the NLEM and Jan Aushadhi list?

We did not find it on NLEM 2022. Yes, several glipizide products are in the Jan Aushadhi list we checked.

Source2

Sources

1U.S. FDA-approved label (DailyMed) (00729e82-150a-464a-abe7-a3319721fbdb) Open source · 2026-10-15
2PMBJP (Jan Aushadhi) product list (p6:sno124) Open source · 2026-10-15

Compiled by software from the sources above and checked by automated rules. Last checked: 2026-10-15 · How we use sources · Report a correction

This information is educational and is not a substitute for advice from your doctor or pharmacist. It does not tell you what dose you personally should take. In an emergency call 112.

Safety at a glance

What is glipizide used for?

How does glipizide work?

How is glipizide usually taken?

What are the side effects of glipizide?

Common

Serious: get help

Who should be careful with glipizide?

What medicines interact with glipizide?

How should glipizide be stored?

Is glipizide a prescription medicine in India?

What is the price ceiling for glipizide?

Frequently asked questions

Sources

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