Lorazepam

The label describes lorazepam tablets for managing anxiety disorders, or for short-term relief of anxiety symptoms, including anxiety linked to depressive symptoms.

The label says everyday stress usually does not need treatment. Its usefulness beyond 4 months has not been studied, and the doctor should reassess it periodically.

• Anxiety disorders
• Short-term relief of anxiety symptoms
• Anxiety with depressive symptoms

The label describes lorazepam binding to the benzodiazepine site of GABA-A receptors in the brain.

This increases the calming action of GABA, a natural brain chemical.

This page covers the US label for lorazepam tablets taken by mouth, with the dosing the label gives for adults.

This is label-level information, not personal advice. Indian pack labels may differ, and your prescriber's instruction always comes first.

The label describes a usual range of 2 to 6 mg a day in divided doses, with the largest dose at bedtime. The daily dose may range from 1 to 10 mg. For anxiety, most patients need an initial 2 to 3 mg a day, given two or three times a day.

For insomnia due to anxiety or temporary stress, a single dose of 2 to 4 mg at bedtime may be given. For elderly or debilitated patients, it describes an initial 1 to 2 mg a day in divided doses.

Doses should be raised gradually. To stop it, the label says to use a gradual taper to reduce withdrawal reactions.

• Usual range 2 to 6 mg a day in divided doses
• Elderly or debilitated: start 1 to 2 mg a day
• Increase gradually
• Taper slowly when stopping

The label warns that using benzodiazepines with opioids can cause profound sedation, slowed breathing, coma, and death. It also warns of abuse, misuse, addiction, dependence, and withdrawal reactions, so a gradual taper is needed when stopping.

It must not be used by people allergic to benzodiazepines or with acute narrow-angle glaucoma. Elderly or debilitated patients need lower doses.

Neonates born to mothers using benzodiazepines late in pregnancy may have sedation or withdrawal symptoms. Do not drive until the effects of use with an opioid are known.

• Serious risk when combined with opioids
• Risk of abuse, addiction, dependence and withdrawal
• Do not use if allergic to benzodiazepines or with narrow-angle glaucoma
• Lower dose in elderly
• Late pregnancy use may cause newborn sedation or withdrawal

• Opioids
• Alcohol and other sedating medicines
• Clozapine
• Valproate
• Probenecid
• The label says using lorazepam with opioids raises the risk of slowed breathing, sedation, coma, and death.
• Other CNS depressants such as alcohol, barbiturates, antipsychotics, sedatives, antidepressants, sedative antihistamines, and anticonvulsants add to the effect.
• Clozapine with lorazepam may cause marked sedation, hypotension, and respiratory arrest.
• Valproate raises lorazepam levels, and its dose should be reduced to about 50 percent.
• Probenecid may speed onset or prolong its effect.

No match in this label text. Ask your pharmacist about any medicine you take.

The label gives a storage range of 20 to 25 degrees C.

The label also says to keep the container tightly closed.

Follow the storage line on your own pack, and keep medicines out of the reach of children.

In the Drugs Rules schedules we checked, lorazepam is listed under Schedule H (serial and rule: Schedule H, serial 294 (rules 65 and 97)). Schedule H medicines are sold only on a registered doctor's prescription.

Lorazepam is on the National List of Essential Medicines 2022. Listed forms include: Injection 2 mg/mL (page 66); Injection 4 mg/mL (page 66).

NPPA lists ceiling prices for scheduled lorazepam formulations. The table shows the rows we found. Check NPPA directly for the current list.

The Jan Aushadhi (PMBJP) list we checked has 3 product rows that mention lorazepam. We did not capture prices for them.

NPPA ceiling prices set the most a seller can charge per unit for the listed formulations, before local taxes. They are ceilings, not the price you will always pay.

Jan Aushadhi lists lorazepam products including Lorazepam Tablets IP 1mg 1mg; Lorazepam Tablets IP 2mg 2mg; Lorazepam Tablets IP 3mg 3mg. We have not shown a price for them. Check the pack and the seller for the actual price.