Omeprazole

The US label for omeprazole delayed-release capsules lists treatment of active duodenal ulcer and active benign gastric ulcer in adults.

It is also used with clarithromycin and amoxicillin to eradicate Helicobacter pylori in adults, to treat symptomatic GERD and erosive esophagitis from acid reflux in people 2 years and older, and to maintain healing of erosive esophagitis.

It is also used in pathological hypersecretory conditions, where the stomach makes too much acid, in adults.

• Active duodenal ulcer
• Active benign gastric ulcer
• H. pylori eradication (with antibiotics)
• Symptomatic GERD
• Erosive esophagitis and maintenance of healing
• Pathological hypersecretory conditions

Omeprazole is a substituted benzimidazole. The label says it suppresses stomach acid by blocking the H+/K+ ATPase enzyme system, known as the acid pump, in stomach cells.

This blocks the final step of acid production, for both basal and stimulated acid.

The US label for adults lists 20 mg once daily for 4 weeks for active duodenal ulcer, with a possible extra 4 weeks. For gastric ulcer it lists 40 mg once daily for 4 to 8 weeks.

For symptomatic GERD it lists 20 mg once daily for up to 4 weeks, and for erosive esophagitis 20 mg once daily for 4 to 8 weeks.

The label says H. pylori regimens combine omeprazole with antibiotics for 10 to 14 days, and that children's doses depend on weight.

The excerpt we reviewed does not describe meal timing. Follow your prescriber's instructions.

Indian pack labels may differ from the US label. Your prescriber's instruction always comes first.

The label says that symptom relief does not rule out stomach cancer, so more testing may be needed.

Long-term and high-dose use may raise the risk of fractures of the hip, wrist or spine, and daily use for over 3 years may cause vitamin B12 deficiency.

It is contraindicated with rilpivirine and in people with allergy to omeprazole or related medicines.

Pregnancy: no adequate studies exist in pregnant women. Epidemiologic data did not show a higher risk of major malformations with first-trimester use.

Breastfeeding: limited data suggest it may be present in milk.

Children: safety has been established for certain uses from 2 to 16 years. Older adults: no dose change is needed.

• Rilpivirine-containing products are contraindicated.
• The label says to avoid atazanavir, nelfinavir, clopidogrel, St.
• John's wort and rifampin with omeprazole.
• Saquinavir levels may rise and need monitoring.
• The label also lists methotrexate among interacting medicines.
• It can also raise chromogranin A, which can interfere with tests for neuroendocrine tumours, and the label advises stopping it at least 14 days before the test.

No match in this label text. Ask your pharmacist about any medicine you take.

The label reports overdoses up to 2400 mg. Effects included confusion, drowsiness, blurred vision, fast heartbeat, nausea, vomiting, sweating, flushing, headache and dry mouth.

Symptoms were transient and no serious outcome was reported when taken alone. There is no specific antidote.

The label text we reviewed for this product does not describe storage conditions, only the pack sizes.

Follow the storage instructions printed on your pack.

In the Drugs Rules 1945 schedules we checked, Omeprazole appears as Schedule H, serial 367 (rules 65 and 97).

The National List of Essential Medicines 2022 lists these forms: Capsule 10 mg; Capsule 20 mg; Capsule 40 mg; Powder for oral liquid 20 mg.

The National Pharmaceutical Pricing Authority (NPPA) lists ceiling prices for the formulations in the table below. A seller cannot charge more than the ceiling per unit.

The banned-combination list we checked mentions Omeprazole in 6 entries. Fixed-dose combinations differ, so check your exact product.

The ceiling price is the most a seller may charge per unit for a scheduled formulation. Actual brand prices are usually at or below it. Check the pack and seller for the real price.

Jan Aushadhi (PMBJP) product rows we found are listed next.

Omeprazole 20mg and Domperidone 10mg Capsules IP, pack 10's.

Omeprazole Gastro-resistant Capsules IP 20 mg, pack 10's.

Omeprazole Gastro-resistant 20mg and Domperidone Sustained Release 30mg Capsules, pack 15's.

Omeprazole 20mg Powder for Oral suspension (Sodium bicarbonate as buffer), pack 10 sachet in monocarton.

We do not show a brand price here. Prices change, so confirm with the seller.