Spironolactone

The label describes spironolactone for primary hyperaldosteronism, including diagnostic testing and long-term maintenance when surgery is not possible.

It is also described for swelling caused by congestive heart failure, cirrhosis of the liver with fluid, and nephrotic syndrome, and for high blood pressure.

• Primary hyperaldosteronism
• Swelling in heart failure
• Swelling and ascites in liver cirrhosis
• Nephrotic syndrome swelling
• High blood pressure

Spironolactone blocks the hormone aldosterone in the kidney tubules. This makes the body pass more sodium and water while keeping potassium.

It acts both as a diuretic and as a blood-pressure-lowering medicine.

This page covers the US label for spironolactone tablets taken by mouth, with the dosing the label gives for adults.

This is label-level information, not personal advice. Indian pack labels may differ, and your prescriber's instruction always comes first.

For swelling in adults, the label describes an initial 100 mg daily in single or divided doses, within a range of 25 to 200 mg daily. It is usually continued at least five days before adjusting.

For primary hyperaldosteronism testing, the label describes 400 mg daily for four days or three to four weeks. Before surgery, 100 to 400 mg daily is described.

• Dose depends on the condition
• Single or divided daily doses
• Lowest effective dose for long-term use
• Blood potassium monitoring is advised

It is contraindicated in anuria, acute kidney failure, significant kidney impairment, high potassium, Addison's disease and with eplerenone.

Potassium supplements, salt substitutes with potassium and potassium-rich diets should not ordinarily be used. Hyperkalemia can be fatal in severe heart failure, so potassium and creatinine need monitoring.

The label notes possible effects on male sex development in pregnancy.

• High potassium risk
• Avoid potassium supplements and salt substitutes
• Not for anuria or severe kidney impairment
• Not with Addison's disease or eplerenone
• Monitor potassium and creatinine

• ACE inhibitors and angiotensin II blockers
• Other potassium-sparing diuretics and potassium supplements
• NSAIDs and heparin
• Lithium
• ACE inhibitors, angiotensin II blockers, other potassium-sparing diuretics, heparin, NSAIDs and potassium supplements can cause severe high potassium.
• Lithium generally should not be given with diuretics.
• NSAIDs may weaken the diuretic effect, and alcohol, barbiturates or narcotics may worsen low blood pressure on standing.

No match in this label text. Ask your pharmacist about any medicine you take.

The label gives a storage range of 20 to 25 degrees C.

The label also says to protect it from light, keep the container tightly closed.

Follow the storage line on your own pack, and keep medicines out of the reach of children.

In the Drugs Rules schedules we checked, spironolactone is listed under Schedule H (serial and rule: Schedule H, serial 468 (rules 65 and 97)). Schedule H medicines are sold only on a registered doctor's prescription.

Spironolactone is on the National List of Essential Medicines 2022. Listed forms include: Tablet 25 mg (page 89); Tablet 50 mg (page 89); Tablet 25 mg (page 93); Tablet 50 mg (page 93).

NPPA lists ceiling prices for scheduled spironolactone formulations. The table shows the rows we found. Check NPPA directly for the current list.

The Jan Aushadhi (PMBJP) list we checked has 4 product rows that mention spironolactone. We did not capture prices for them.

NPPA ceiling prices set the most a seller can charge per unit for the listed formulations, before local taxes. They are ceilings, not the price you will always pay.

Jan Aushadhi lists spironolactone products including Spironolactone Tablets IP 25 mg 25 mg; Spironolactone 50mg and Torasemide 20mg Tablets 50mg; Spironolactone Tablets IP 50 mg 50 mg; Spironolactone Tablets IP 100mg 100mg. We have not shown a price for them. Check the pack and the seller for the actual price.