Tizanidine

The label describes tizanidine as a short-acting drug for the management of spasticity.

Because the effect is brief, treatment is reserved for daily activities and times when relief of spasticity is most important.

• Management of spasticity
• Used at times when relief is most needed

The label says tizanidine acts on alpha-2 adrenergic receptors and is thought to reduce spasticity by increasing inhibition of motor nerve cells. It is chemically related to clonidine.

This page covers the US label for tizanidine tablets taken by mouth, with the dosing the label gives for adults.

This is label-level information, not personal advice. Indian pack labels may differ, and your prescriber's instruction always comes first.

The label suggests beginning with single oral doses of 4 mg. The dose is then raised gradually in steps of 2 to 4 mg to the best effect at a tolerated dose.

Doses can be repeated at 6 to 8 hour intervals as needed, up to three doses in 24 hours. The total daily dose should not exceed 36 mg.

A single 8 mg dose peaks at 1 to 2 hours and wears off in 3 to 6 hours. The label says food changes how the drug behaves, so switching between fed and fasted dosing can change effects.

• Start with 4 mg doses
• Increase in 2 to 4 mg steps
• Repeat every 6 to 8 hours, up to 3 doses a day
• Not more than 36 mg in 24 hours

Tizanidine can lower blood pressure. The label says to raise doses gradually and watch for signs of low blood pressure, particularly when moving from lying to upright.

It is contraindicated with fluvoxamine or ciprofloxacin and in known hypersensitivity. The label notes limited long-term experience with single doses above 8 mg and daily doses above 24 mg.

• Can cause low blood pressure
• Contraindicated with fluvoxamine or ciprofloxacin
• Limited experience with high doses
• Switching between fed and fasted states can change effects

• Fluvoxamine and ciprofloxacin (contraindicated)
• Other CYP1A2 inhibitors
• Oral contraceptives, certain heart medicines and antibiotics
• The label says fluvoxamine and ciprofloxacin strongly raise tizanidine levels and are contraindicated.
• They cause large falls in blood pressure and more drowsiness.
• Other drugs that block CYP1A2, such as some fluoroquinolones, amiodarone, verapamil, cimetidine, famotidine, oral contraceptives and acyclovir, may also raise levels.

No match in this label text. Ask your pharmacist about any medicine you take.

The label also says to keep the container tightly closed.

Follow the storage line on your own pack, and keep medicines out of the reach of children.

In the Drugs Rules schedules we checked, tizanidine is listed under Schedule H (serial and rule: Schedule H, serial 502 (rules 65 and 97)). Schedule H medicines are sold only on a registered doctor's prescription.

We did not find tizanidine on the National List of Essential Medicines 2022 in the list we checked.

The Jan Aushadhi (PMBJP) list we checked has 1 product row that mention tizanidine. We did not capture prices for them.

The banned fixed-dose combination list we checked has 1 entries that mention tizanidine. This does not mean the single medicine is banned. Use our checker for a specific combination.

Jan Aushadhi lists tizanidine products including Tizanidine Tablets I.P 2mg 2mg. We have not shown a price for them. Check the pack and the seller for the actual price.